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Index > Protein center > Corin(Gene name) > Mouse
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  • Corin (Gene name),
  • Atrial natriuretic peptide-converting enzyme (Protein name ),  CORIN_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Corin(Crn;Lrp4);
    Protein name:
    Atrial natriuretic peptide-converting enzyme;
    Alternative:
    Low density lipoprotein receptor-related protein 4;Corin;Pro-ANP-converting enzyme;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    1113
    Sequence:
    50:
    MGRVSFSVRV | SSVRRARCSC | PGRCYLSCRV | PPTTALRALN | GLGCAGVPGE | 
    100:
    TAGGAVGPGP | LGTRGFLSGS | KFQAPGSWKD | CFGAPPAPDV | LRADRSVGEG | 
    150:
    CPQKLVTANL | LRFLLLVLIP | CICALIVLLA | ILLSFVGTLK | RVYFKSNDSE | 
    200:
    PLVTDGEARV | PGVIPVNTVY | YENTGAPSLP | PSQSTPAWTP | RAPSPEDQSH | 
    250:
    RNTSTCMNIT | HSQCQILPYH | STLAPLLPIV | KNMDMEKFLK | FFTYLHRLSC | 
    300:
    YQHILLFGCS | LAFPECVVDG | DDRHGLLPCR | SFCEAAKEGC | ESVLGMVNSS | 
    350:
    WPDSLRCSQF | RDHTETNSSV | RKSCFSLQQE | HGKQSLCGGG | ESFLCTSGLC | 
    400:
    VPKKLQCNGY | NDCDDWSDEA | HCNCSKDLFH | CGTGKCLHYS | LLCDGYDDCG | 
    450:
    DLSDEQNCDC | NLTKEHRCGD | GRCIAAEWVC | DGDHDCVDKS | DEVNCSCHSQ | 
    500:
    GLVECRSGQC | IPSTFQCDGD | EDCKDGSDEE | NCSDSQTPCP | EGEQGCLGSS | 
    550:
    CVESCAGSSL | CDSDSSLSNC | SQCEPITLEL | CMNLPYNHTH | YPNYLGHRTQ | 
    600:
    KEASISWESS | LFPALVQTNC | YKYLMFFACT | ILVPKCDVNT | GQRIPPCRLL | 
    650:
    CEHSKERCES | VLGIVGLQWP | EDTDCNQFPE | ESSDNQTCLL | PNEDVEECSP | 
    700:
    SHFKCRSGRC | VLGSRRCDGQ | ADCDDDSDEE | NCGCKERALW | ECPFNKQCLK | 
    750:
    HTLICDGFPD | CPDSMDEKNC | SFCQDNELEC | ANHECVPRDL | WCDGWVDCSD | 
    800:
    SSDEWGCVTL | SKNGNSSSLL | TVHKSAKEHH | VCADGWRETL | SQLACKQMGL | 
    850:
    GEPSVTKLIP | GQEGQQWLRL | YPNWENLNGS | TLQELLVYRH | SCPSRSEISL | 
    900:
    LCSKQDCGRR | PAARMNKRIL | GGRTSRPGRW | PWQCSLQSEP | SGHICGCVLI | 
    950:
    AKKWVLTVAH | CFEGREDADV | WKVVFGINNL | DHPSGFMQTR | FVKTILLHPR | 
    1000:
    YSRAVVDYDI | SVVELSDDIN | ETSYVRPVCL | PSPEEYLEPD | TYCYITGWGH | 
    1050:
    MGNKMPFKLQ | EGEVRIIPLE | QCQSYFDMKT | ITNRMICAGY | ESGTVDSCMG | 
    1100:
    DSGGPLVCER | PGGQWTLFGL | TSWGSVCFSK | VLGPGVYSNV | SYFVGWIERQ | 
    1113:
    IYIQTFLQKK | SQG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    E1930m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    E1930h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    E1930r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    U1930r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    U1930h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    U1930m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    P1930Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    P1930Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Atrial natriuretic peptide-converting enzyme
    Cat.:
    P1930Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Atrial natriuretic peptide-converting enzyme
    Monoclonal Antibody for Mouse Atrial natriuretic peptide-converting enzyme
    Monoclonal Antibody for Mouse Atrial natriuretic peptide-converting enzyme
    Protein for Mouse Atrial natriuretic peptide-converting enzyme
    Protein for Mouse Atrial natriuretic peptide-converting enzyme
    Protein for Mouse Atrial natriuretic peptide-converting enzyme

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart."
      Tomita Y. , Kim D.-H. , Magoori K. , Fujino T. , Yamamoto T.T.
      J. Biochem.124:784-789(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6.
      tissue: Brain.
      tissue: Head.
    5. 5.
      "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes."
      Wu F. , Yan W. , Pan J. , Morser J. , Wu Q.
      J. Biol. Chem.277:16900-16905(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Hypertension in mice lacking the proatrial natriuretic peptide convertase corin."
      Chan J.C. , Knudson O. , Wu F. , Morser J. , Dole W.P. , Wu Q.
      Proc. Natl. Acad. Sci. U.S.A.102:785-790(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    7. 7.
      "Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases."
      Polzin D. , Kaminski H.J. , Kastner C. , Wang W. , Kramer S. , Gambaryan S. , Russwurm M. , Peters H. , Wu Q. , Vandewalle A. , Bachmann S. , Theilig F.
      Kidney Int.78:650-659(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Human corin isoforms with different cytoplasmic tails that alter cell surface targeting."
      Qi X. , Jiang J. , Zhu M. , Wu Q.
      J. Biol. Chem.286:20963-20969(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
    9. 9.
      "Corin-deficient W-sh mice poorly tolerate increased cardiac afterload."
      Buckley C.L. , Stokes A.J.
      Regul. Pept.172:44-50(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION IN W-SH MODEL MICE
    10. 10.
      "Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice."
      Wang W. , Shen J. , Cui Y. , Jiang J. , Chen S. , Peng J. , Wu Q.
      Kidney Int.82:26-33(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    11. 11.
      "Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy."
      Cui Y. , Wang W. , Dong N. , Lou J. , Srinivasan D.K. , Cheng W. , Huang X. , Liu M. , Fang C. , Peng J. , Chen S. , Wu S. , Liu Z. , Dong L. , Zhou Y. , Wu Q.
      Nature484:246-250(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
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